Laboratory of Molecular Image on Translational Research
awards and news
榮獲今年 #國科會「#2025未來科技獎」殊榮
中國醫藥大學醫學系鄭隆賓講座教授帶領的科研團隊，與國立中央大學攜手合作，運用非病毒基因轉殖技術，建立創新的「多類型基因精準遞送之間質幹細胞平台建構：跨癌種精準免疫療法的新策略」。
團隊以低免疫原性的臍帶間質幹細胞為載體，成功導入多重治療基因，精準作用於腫瘤微環境，實現同步抗腫瘤與免疫調控。
主要成員包括中國醫藥大學生醫所特聘教授徐偉成醫師，以及國立中央大學生命科學系許斐婷副教授。
Recipient of the 2025 Future Tech Award from the National Science and Technology Council (NSTC).
A research team led by Distinguished Professor Lung-Bin Cheng of the School of Medicine, China Medical University, in collaboration with National Central University, has developed an innovative platform titled “Construction of a Multimodal Gene-Precision Delivery Mesenchymal Stem Cell System: A New Strategy for Cross-Cancer Precision Immunotherapy.”
Using non-viral gene transfection technology, the team established a mesenchymal stem cell platform based on low-immunogenic umbilical cord-derived MSCs as delivery vehicles. This system enables the precise introduction of multiple therapeutic genes that act specifically within the tumor microenvironment, achieving simultaneous anti-tumor and immune-regulatory effects.
Key members of the collaborative team include Professor Wei-Cheng Hsu of the Graduate Institute of Biomedical Sciences, China Medical University, and Associate Professor Fei-Ting Hsu of the Department of Life Sciences, National Central University.
research resources
Main resources and equipment in LMITR
Our lab equip with following equipment including luminescence fluorescent imaging system (SpectraMax iD3), mouse surgical microscope platform and system, biomedical image analysis software (PMOD), luminescence imaging system (UVP ChemiDoc-It imaging system), Flow Cytometry (ACEA biosciences. Inc. NOVOCYTE), tissue homogenization system (gentleMACS™ Dissociator)... etc. The above-mentioned equipment can be used for the application of nanomaterials in cancer treatment and biomedical imaging.
Cooperators:
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Center for Advance Molecular Imaging and Translation, Chang Gung Memoiral Hospital, New Taipei City
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China Medical University Hospital, Taichung
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Institute of Nuclear Energy Research, Atomic Energy Council, Taoyuan City
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Taipei Medical University, Taipei
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National Cheng Kung University, Tainan
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National Yang Ming Chiao Tung University, Taipei
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The University of Melbourne, Australia
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Centre For Eye Research Australia
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New York University, USA
research projects
Gene Modified Mesenchymal Stem Cell Therapy and Diagnosis
Due to the characteristic of WJ-MSCs, we hypothesis that WJ-MSCs can be a cell carrier to delivery multi-targeted vectors which may markedly enhance the therapeutic efficacy of glioblastoma.
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Molecular Image Application on Cancer
1. Bioluminescence Imaging
2. Micro Positron Emission Tomography
3. MR Chemical Exchange Saturation Transfer
4. Magnetic resonance imaging (MRI)
Theranostic
1. Molecular Magnetic Resonance Imaging (mMRI)
(Superparamagnetic iron oxide based MRI contrast agents)
2. Drug delivery efficacy (covert by MR signal intensity)
Molecular Image Application on Immunology
Anti-bodies based immunotherapy
Bioluminescence Imaging
(Luminescence-based reporter gene model )
1. Low dose chemo combined adoptive T transfer
2. Antibody combination treatment
CONTACT ME
QUICK ID
Phone
Website
Address
+886-3-4227151#65085
https://1440114.wixsite.com/sakiro920
No. 300, Zhongda Rd., Zhongli District, Taoyuan City 320317, Taiwan (R.O.C.) 科學五館208/404
Woei-Cheang Shyu
Professor
Graduate Institute of Biomedical Sciences Professor
China Medical University
Keng-Li Lan
Associate Professor
Institute of Traditional Medicine
School of Medicine
National Yang-Ming University
Chih-Chia Huang
Professor
Department of Photonic
National Cheng-Kung University